I am having the same 'Skype 4 problem' as Bob with both Marine Aquarium 3 (Beta9b) and Dream Aquarium 1.207.
I have a Dell Precision Workstation 380 running Vista Business SP1 32-bit with 4Gb Ram and an nVidia Quadro FX 3500 graphics card.
Almost always, neither screensaver will run while Skype 4 is running. However, once I quit Skype 4, both can be started consistently.
Uninstalling Skype 4 and replacing it with Skype 3.8.0.188 'solves' the problem.
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