Maybe someone who's experiencing the problem could check the Key while the program is working normally, then again the next time it asks for a Key. (The entry will not be your actual Key Code, it is "munged" before being copied to the Registry.)
If the RegCode entry is still intact, then the problem might be something we have control over. If it's gone or zeroed-out, then it's a Microsoft thing.
The Registry entry is:
Current User/software/SereneScreen/MarineAquarium3/RegCode
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